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8016 matches
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organism
protein
1)
Escherichia coli K12
yegS - Phosphatidylglycerol
kinase
, metal-dependent; In vitro phosphorylates phosphatidylglycerol but not diacylglycerol; the in vivo substrate is unknown; Belongs to the diacylglycerol/lipid
kinase
family. YegS
lipid
kinase
subfamily.
[a.k.a. b2086, AAC75147.1, NP_416590.1,
Lipid kinase
]
2)
Homo sapiens
COQ8A - Atypical
kinase
COQ8A, mitochondrial; Atypical
kinase
involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential
lipid
-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: does not show any protein
kinase
activity. Probably acts as a small molecule
kinase
, possibly a
lipid
kinase
that phosphorylates a prenyl
lipid
in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q
lipid
intermediates. Shows an unusual selectivity for binding ADP over ATP.
[a.k.a. CCDS1557.1, uc001hqm.2, XM_017001852]
3)
Homo sapiens
COQ8B - Atypical
kinase
COQ8B, mitochondrial; Atypical
kinase
involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential
lipid
-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: does not show any protein
kinase
activity. Probably acts as a small molecule
kinase
, possibly a
lipid
kinase
that phosphorylates a prenyl
lipid
in the ubiquinone biosynthesis pathway. Required for podocyte migration.
[a.k.a. ENST00000243583, ENSP00000315118, ENST00000594490]
4)
Homo sapiens
AGK - Acylglycerol
kinase
, mitochondrial;
Lipid
kinase
that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Phosphorylates ceramide (By similarity). Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3- dioleoylglycerol (By similarity). Independently of its
lipid
kinase
activity, acts as a component of the TIM22 complex. The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin- [...]
[a.k.a. ENST00000473247.5, NP_060708.1, AGK-224]
5)
Homo sapiens
SH3GLB1 - Endophilin-B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion. Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase- independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates
lipid
kinase
activity of PIK3C3 during autophagy probably by [...]
[a.k.a. ENST00000370558, XM_006710672.2, NM_001206653.1]
6)
Homo sapiens
DGKQ - Diacylglycerol
kinase
theta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein
kinase
C by controlling the balance between these two signaling
lipids
. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP-induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity.
[a.k.a. R-HSA-388396, uc003gbw.5, ENSP00000372443]
7)
Homo sapiens
PI4K2A - Phosphatidylinositol 4-
kinase
type 2-alpha; Membrane-bound phosphatidylinositol-4
kinase
(PI4-
kinase
) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a
lipid
that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4- phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second mess [...]
[a.k.a. 55361, Q9NSG8, ENSG00000155252]
8)
Homo sapiens
SPHK1 - Sphingosine
kinase
1; Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a
lipid
mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other
lipids
, such as D,L-threo- dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. In contrast to proapoptotic SPHK2, has a negative effect on intracellular ceramide levels, enhances cell growth and inhibits apoptosis. Involved in the regulation of inflammatory response and neuroinflammation. Via [...]
[a.k.a. AF266756, ENSP00000465726, uc002jrf.1]
9)
Homo sapiens
SPHK2 - Sphingosine
kinase
2; Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a
lipid
mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D- erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides. In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis. In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulat [...]
[a.k.a. NP_064511.2, HGNC:18859, R-HSA-556833]
10)
Homo sapiens
SCIMP - SLP adapter and CSK-interacting membrane protein;
Lipid
tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family
kinases
and other signaling proteins in immune cells. It is involved in major histocompatibility complex class II (MHC-II) signaling transduction in B cells, where it is required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation. In dendritic cells, it is involved in sustaining CLEC7A/DECTIN1 signaling after CLEC7A activation by fungal beta-glucans (By similarity). It also acts as an agonist-inducible si [...]
[a.k.a. NP_996986, ENSG00000161929, 388325]
11)
Homo sapiens
PACSIN2 - Protein
kinase
C and casein
kinase
substrate in neurons protein 2; Regulates the morphogenesis and endocytosis of caveolae (By similarity).
Lipid
-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. Belongs to the PACSIN family.
[a.k.a. AL136845, NM_001184971, ENST00000407585.5]
12)
Homo sapiens
UNC119 - Protein unc-119 homolog A; Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family
kinase
activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as
lipid
-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Proba [...]
[a.k.a. CCDS82094.1, HRG4, UPI000268AF88]
13)
Homo sapiens
INPP5E - Phosphatidylinositol polyphosphate 5-phosphatase type IV; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Specific for
lipid
substrates, inactive towards water soluble inositol phosphates. Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-
kinase
(PI3K) signaling and stability (By similarity); Belongs to the in [...]
[a.k.a. uc004cho.4, R-HSA-1483255, R-HSA-556833]
14)
Homo sapiens
FGFR4 - Fibroblast growth factor receptor 4; Tyrosine-protein
kinase
that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of
lipid
metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down- regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation o [...]
[a.k.a. JN007482, R-HSA-9006925, R-HSA-5654716]
15)
Homo sapiens
PRKAG2 - 5'-AMP-activated protein
kinase
subunit gamma-2; AMP/ATP-binding subunit of AMP-activated protein
kinase
(AMPK), an energy sensor protein
kinase
that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and
lipid
biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...]
[a.k.a. UPI0001B792B9, ENSP00000419272, PRKAG2-213]
16)
Homo sapiens
PRKAG1 - 5'-AMP-activated protein
kinase
subunit gamma-1; AMP/ATP-binding subunit of AMP-activated protein
kinase
(AMPK), an energy sensor protein
kinase
that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and
lipid
biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...]
[a.k.a. ENSP00000449121, UPI0003F47C41, 6C9F]
17)
Homo sapiens
PRKAG3 - 5'-AMP-activated protein
kinase
subunit gamma-3; AMP/ATP-binding subunit of AMP-activated protein
kinase
(AMPK), an energy sensor protein
kinase
that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and
lipid
biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...]
[a.k.a. ENSP00000419272, ENST00000392098, NP_059127.2]
18)
Homo sapiens
PRKAA1 - 5'-AMP-activated protein
kinase
catalytic subunit alpha-1; Catalytic subunit of AMP-activated protein
kinase
(AMPK), an energy sensor protein
kinase
that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and
lipid
biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...]
[a.k.a. ENST00000397127, Q5D0E1, UPI000020C9F6]
19)
Homo sapiens
PRKAA2 - 5'-AMP-activated protein
kinase
catalytic subunit alpha-2; Catalytic subunit of AMP-activated protein
kinase
(AMPK), an energy sensor protein
kinase
that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and
lipid
biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...]
[a.k.a. OTTHUMG00000008282, R-HSA-162582, R-HSA-556833]
20)
Homo sapiens
PRKAB2 - 5'-AMP-activated protein
kinase
subunit beta-2; Non-catalytic subunit of AMP-activated protein
kinase
(AMPK), an energy sensor protein
kinase
that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and
lipid
biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...]
[a.k.a. ENSP00000415469, AJ224538, URS0000D6D572]
8016 matches
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